The purpose of this article is to review the current state of the art of using vertebral augmentation techniques for treating symptomatic spinal fractures that are associated with malignant lesions and to present potential future trends in treatments for this patient population. Epidemiology and biomechanical ramifications of these lesions are summarized, and treatment regimes, clinical outcomes, complications, and technical issues associated with treatments are presented. Potential future trends and new technologies for performing vertebral body augmentation in patients with metastatic spinal lesions are also discussed in this article.